2. Search Result

Search Result

Results for " HY-N6727 " in MedChemExpress (MCE) Product Catalog:

Inhibitors & Agonists

Cat. No. Product Name Target Research Area
  • HY-N6727
    Gliotoxin Apoptosis; PKA; NF-κB; Bacterial; Fungal; Antibiotic Inflammation/Immunology; Infection; Cancer
    Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells [1]. Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis[2]. Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells[3]. Gliotoxin is a potent NOTCH2 transactivation inhibitor, can effectively induce apoptosis of chronic lymphocytic leukemia (CLL) cells[4].

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity: